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대한생식의학회지 제32권 제2호 2010년
한국인 여성에서 중증 자궁내막증의 발생 위험도와 CYP19 유전자 다형성과의 관련성에 관한 연구
이화여자대학교 의과대학 산부인과학교실, 건국대학교 의과대학 산부인과학교실1
허성은,, 이지영1,문혜성,정혜원
No association of Polymorphism in the Estrogen-synthesizing Enzyme Genes CYP19 with Advanced Endometriosis in Korean Women
Sung Eun Hur, Ji Young Lee1, Hye Sung Moon, Hye Won Chung
Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul, Korea, Department of Obstetrics and Gynecology, 1College of Medicine, KonKuk University, Seoul, Korea
.
Objective: To investigate whether polymorphism of CYP19 gene is associated with the risk of advanced endometriosis in Korean women. Methods: Blood samples were collected from 202 endometriosis patients and 221 controls. The patients with endometriosis of stages III and IV diagnosed by both pathologic and laparoscopic findings to according modified AFS classification. The women undergoing laparoscopic surgery or laparotomy for non-malignant lesions were included in the control group. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine all individuals' genotype. Results: The heterozygous allele in CYP19 gene was the most common genotypes in both endometriosis and healthy control groups (52.0% vs. 46.1%). CYP19 gene polymorphisms did not show the significant differences between the control group and endometriosis group. Conclusion: The results suggested that the CYP19 genetic polymorphism was not associated with a risk of advanced endometriosis in Korean women.
키워드 : CYP19, Endometriosis, Polymorphism
교신저자 : hyewon@ewha.ac.kr
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