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대한생식의학회지 제35권 제4호 2010년
한국 여성에서 중증 자궁내막증과 Human α2-Heremans Schmidt Glycoprotein (AHSG) 유전자 다형성의 연관성
서울대학교 의과대학 산부인과학교실1, 의학연구원 인구의학연구소2, 서울마리아 불임병원3,가천의과학대학교 산부인과학교실4, 울산대학교 의과대학 산부인과학교실5,고려대학교 의과대학 산부인과학교실6, 경북대학교 의과대학 산부인과학교실7,연세대학교 의과대학 산부인과학교실8, 전남대학교 의과대학 산부인과학교실9,부산대학교 의과대학 산부인과학교실10, 가톨릭대학교 의과대학 산부인과학교실11
김진주1•채수진3•김종미1•이경훈4•최영민1,2*•김성훈5•신정호6•이택후7허준용6•이병석8•오성택9•이규섭10•임용택11,
Association between Endometriosis and Human α2-Heremans Schmidt Glycoprotein (AHSG) Polymorphism
Jin Ju Kim1, Soo Jin Chae3, Jong Mee Kim1, Gyoung Hoon Lee4, Young Min Choi1,2*,Sung Hoon Kim5, Jung Ho Shin6, Taek Hoo Lee7, Jun Young Hur6, Byoung Suk Lee8,Sung Tack Oh9, Kyu Sup Lee10, Young Tack Lim11
1Department of Obstetrics and Gynecology,2Institute of Reproductive Medicine and Population,Medical Research Center,Seoul National University College of Medicine; 3Department of Obstetrics and Gynecology,Maria Fertility Hospital; 4Department of Obstetrics and Gynecology,Gachon University Gil Medical Center;5Department of Obstetrics and Gynecology,College of Medicine,University of Ulsan,Asan Medical Center;6Department of Obstetrics and Gynecology,Korea University College of Medicine; 7Department of Obstetrics and Gynecology,Kyungpook National University School of Medicine; 8Department of Obstetrics and Gynecology,Yonsei University College of Medicine; 9Department of Obstetrics and Gynecology,Chonnam National University College of Medicine; 10Department of Obstetrics and Gynecology,Pusan National University College of Medicine and Medical Research Institute,Pusan National University; 11Department of Obstetrics and Gynecology,St Vincent's Hospital,College of Medicine,Catholic University
Objective: To evaluate the relationship between advanced stage endometriosis and polymorphisms in α2-Heremans Schmidt glycoprotein (AHSG) gene in Korean women. Methods: One-hundred thirty women with endometriosis stage III and IV, and 224 women without endometriosis were enrolled. In these patients, we determined AHSG gene polymorphisms by PCR and RFLP (restriction fragment length polymorphism) analysis. Results: The genotype distribution of the AHSG gene polymorphism in the endometriosis group was not different from that of the control group (AHSG 1*1/AHSG 1*2/AHSG 2*2 frequencies were 56.2%/37.7%/6.2% and 55.8%/39.3%/4.9% for the endometriosis and control groups, respectively, p=.864). Also, the frequency of AHSG 2 haplotype was not different between endometriosis patients and controls (AHSG 1 haplotype /AHSG 2 haplotype rates were 75.0%/25.0% and 75.4%/24.6% for the endometriosis and control groups, respectively, p=0.894). Conclusion: AHSG gene polymorphism was not associated with the risk of advanced stage endometriosis in the Korean population.
키워드 : Endometriosis, AHSG, Polymorphism
교신저자 : ymchoi@snu.ac.kr
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