| 학회지 검색 | HOME > 논문 및 학회지 > 학회지 검색 |
대한생식의학회지 제31권 제4호 2010년
체외수정시술을 위한 과배란유도에 있어 GnRH Antagonist의 임상적 효용성과 혈중 호르몬 농도의 변화
서울대학교 의과대학 산부인과학교실1,서울대학교 의학연구원 인구의학연구소2
문신용1,2, 천은경1,김상돈1,최영식1,지병철1,구승엽1,2,서창석1,2,최영민1,2,김정구1,김석현1,2
Clinical Efficacy and Hormonal Change of GnRH Antagonist in Controlled Ovarian Stimulation for IVF-ET
Shin Yong Moon1,2, Eun Kyung Chun1, Sang Don Kim1, Young Sik Choi1,Byung Chul Jee1, Seung-Yup Ku1,2, Chang Suk Suh1,2, Young Min Choi1,2,Jung Gu Kim1, Seok Hyun Kim1,2
1Department of Obstetrics and Gynecology, College of Medicine,2Institute of Reproductive Medicine and Population, Medical Research Center,Seoul National University, Seoul, Korea
Objectives: To evaluate the efficacy of GnRH antagonist cetrorelix in women undergoing controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) and to determine changes in serum hormone concentrations during cetrorelix administration. Methods: We performed a clinical trial on 30 patients undergoing COH with highly purified follicular stimulating hormone (HP-FSH) and gonadotropin releasing hormone antagonist (GnRHant), cetrorelix. FSH was administrated from day 2 or 3 of cycle with fixed dose and adjusted according to individual response. 0.25 mg of cetrorelix was injected daily subcutaneously from stimulation day 5 until the day of hCG administration. Daily ultrasound monitoring was performed for growing follicles and serum levels of luteinizing hormone (LH), estradiol (E2) and progesterone were measured daily during cetrorelix administration. Up to 4 embryos were transferred. Results: Mean age of enrolled patients was 32.0¡¾3.4 years (mean ¡¾ S.D.). All of 30 patients underwent oocyte pick-up, and embryo transfer was done in 28 patients. The total and mean numbers of received oocytes were 196 and 6.5¡¾4.7, the number of fertilized eggs was 111, and the fertilization rate was 56.6%. Total duration of FSH administration was 9.2¡¾2.2 days and mean of 24.3¡¾7.7 ampules of HP-FSH was administered. Total duration of cetrorelix administration was 5.7¡¾1.9 days. Serum LH and progesterone levels were maintained in the range of 1.4~2.9 mIU/mL and 0.3~0.6 ng/ mL, which respectively reflected effective prevention of premature LH surge. Clinical pregnancies were achieved in 9 patients, and overall clinical pregnancy rate was 30.0% per oocyte retrieval, and 32.1% per embryo transfer. Conclusion: GnRH antagonist is safe and convenient for COH for IVF-ET and effective with optimal pregnancy rate.
키워드 : GnRH antagonist, Controlled ovarian hyperstimulation (COH), In vitro fertilization and embryo transfer (IVF-ET)
교신저자 : webmaster@ksfs.or.kr
전문 파일 : 
