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대한생식의학회지 제31권 제4호 2010년
정자형성 과정에서 Vascular Endothelial Growth Factor 및 Endothelin-1 발현의 면역조직화학적 연구
부산대학교 의과대학 비뇨기과학교실
박성우, 박현준,박남철
The Influences of Vascular Endothlelial Growth Factor and Endothelin-1 on Speramtogenesis in Testis
Sung Woo Park, Hyun Jun Park, Nam Cheol Park
Department of Urology, Pusan National University Hospital, Pusan, Korea
Objective: The effects on spermatogenesis by expression of vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) were investigated. Materials and Methods: Testicular specimens were obtained from 40 infertile males due to primary testicular failure and from 10 fertile males with other urologic problems. The specimens of infertile males were devided into 4 groups according to histologic findings; Sertoli cell only syndrome (A), maturation arrest (B), hypospermatogenesis (C) and sloughing and disorganization (D). VEGF and ET-1 expression were detected with immunohistochemical stain. Results: VEGF expression on Leydig cell was detected in all cases. But, VEGF expression rates on germ cell were significantly higher in infertile group B, C, D compared to that of the control group (p<0.05). ET-1 expression rates on Leydig cell was significantly lower in all infertile group compared to that of the control group (p<0.05). But, ET-1 expression rates on Sertoli cell was significantly higher in all infertile group compared to that of the control group (p>0.05). In germ cell of infertile group, LH, FSH and prolactin were significantly decreased, and estradiol is increased in positive stain group on ET-1 immunohistochemical stain (p<0.05). VEGF and ET-1 expression were not correlated mean seminiferous tubule diameter (p>0.05). Conclusions: Abnormal spermatogenesis would be reflected in VEGF expression in germ cell.
키워드 : Vascular endothelial growth factor, Endothelin-1, Spermatogenesis, Testis
교신저자 : pnc@pusan.ac.kr
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