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대한생식의학회지 제34권 제3호 2010년
난포성장 발달에 있어서 TGF-β Superfamily의 작용
국립독성연구원 약리연구부 임상약리팀
노재숙,
Actions of the TGF Superfamily Members in Ovarian Follicle Growth and Development
Jae sook Roh
Department of Pharmacological Research, National Institute of Toxicological Research, Seoul, Korea
.
In conclusion, the members of the TGF-β superfamily act as stage- and cell-specific paracrine factors that, in conjunction with the steroid hormones, the gonadotropins, and other growth factors, orchestrate the timely growth and development of the follicle (summarized in Figure 1). These factors influence the differentiation and proliferation of granulosa cells, the ecruitment of the theca cell layer, the maturation of the oocyte, and steroidogenesis. Research continues to clarify the roles of each of these factors as well as unravel their relationships with one another, with other factors, and with ovarian cell structures with the goal of understanding how a follicle is guided from a primordial follicle to a follicle competent for ovulation. [Korean. J. Reprod. Med. 2007; 34(3): 139-148.]
키워드 : .
교신저자 : rohjs@kfda.go.kr
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