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대한생식의학회지 제34권 제4호 2010년
Estrogen in Female Reproductive Axis: Positive Estrogen Feedback to Pituitary
Center of Excellence in Reproductive Sciences, Department of Clinical Sciences, University of Kentucky, Lexington
Chemyong Ko, Mary C Gieske, Susan Hudgins-Spivey, Phillip Bridges, Sungeun Lee
Estrogen in Female Reproductive Axis: Positive Estrogen Feedback to Pituitary
Center of Excellence in Reproductive Sciences, Department of Clinical Sciences, University of Kentucky, Lexington
New tools such as conditional knockout mice are allowing a clearer picture of the role of estrogen in exerting positive feedback to the hypothalamus and pituitary to induce the LH surge. Current evidence indicates that both the hypothalamus and pituitary are critical in mediating the estrogen signal to induce the LH surge. In particular, ERα may have a role in preparing a unique set of players which equip the pituitary gonadotroph to efficiently release a large amount of LH hormone over a short period. These players are speculated to be involved in positioning gonadotrophs close to blood vessels, localizing LH vesicles to the membrane,and increasing the responsiveness of gonadotrophs to GnRH.
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교신저자 : cko2@uky.edu
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