논문 및 학회지

대한생식의학회지   제27권 제3호 2010년

착상전 유전진단을 이용하여 성공적으로 분만한 반복자연유산 1례

포천중문의과대학 산부인과학교실, 남성불임연구실1, 유전학연구실2, 체외수정연구실2

남윤성, 이숙환, 엄기붕1, 이은정2, 정형민3, 차광열,

A Case of Recurrent Spontaneous Abortion Successfully Delivered by Using Preimplantation Genetic Diagnosis

Yoon Sung Nam, Sook Hwan Lee, Ki Bung Oum1, Eun Jung Lee2, Hyung Min Chung3, Kwang Yul Cha

Department of Obstetrics and Gynecology, Department of Andrology, 1Department of Genetics, 2Department of Embryology, 3College of Medicine, Pocheon CHA University, Pocheon, Korea

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Objective: To report the successful delivery in a patient of recurrent spontaneous abortion caused by chromosomal abnormality. Material and Method: Case report. Results: Twelve oocytes were obtained by in vitro fertilization. Of eleven oocytes fertilized, two embryos turned out to be normal by using fluorescent in situ hybridization on blastomere biopsy. The patient succeeded in pregnancy and the result of amniocentesis was found to be normal. She delivered the healthy female baby by cesarean section. Conclusions: The successful delivery is possible in recurrent spontaneous abortion related with reciprocal translocation by using preimplantation genetic diagnosis.

키워드 : Recurrent spontaneous abortion, Preimplantation genetic diagnosis

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