| 학회지 검색 | HOME > 논문 및 학회지 > 학회지 검색 |
대한생식의학회지 제35권 제2호 2010년
신선 고환조직 정자와 냉동보존-융해 고환조직 정자를 이용한 난자세포질내 정자주입술 결과의 비교 연구
연세대학교 의과대학 산부인과학교실1, 서울대학교 의과대학 산부인과학교실2, 서울대학교 의학연구원 인구의학연구소3, 서울대학교 의과대학 비뇨기과학교실4
최영식1, 최영민2,3*, 김수웅4, 백재승4, 지병철2, 구승엽2,3, 서창석2,3 김석현2,3, 김정구2,3, 문신용2,3,
Comparison of ICSI Outcomes between Fresh and Cryopreserved-Thawed Testicular Spermatozoa
Young Sik Choi1, Young Min Choi2,3*, Soo Woong Kim4, Jae-Seung Paick4, Byung Chul Jee2, Seung-Yup Ku2,3, Chang Suk Suh2,3, Seok Hyun Kim2,3, Jung Gu Kim2,3, Shin Yong Moon2,3
1Department of Obstetrics and Gynecology, Yonsei University College of Medicine, 2Department of Obstetrics and Gynecology, College of Medicine, 3Institute of Reproductive Medicine and Population, Medical Research Center, 4Department of Urology, College of Medicine, Seoul National University, Seoul, Korea
.
Objective: To compare the outcomes of intracytoplasmic sperm injection (ICSI) with fresh and cryopreserved-thawed testicular spermatozoa in patients with azoospermia. Methods: One hundred and nine cycles (66 couples) where ICSI was planned with fresh or cryopreserved-thawed testicular spermatozoa were included in this study; Ninety two cycles (61 couples) with fresh testicular spermatozoa (fresh group) and seventeen cycles (13 couples) with cryopreserved-thawed testicular spermatozoa (cryopreserved-thawed group). We compared ICSI outcomes such as fertilization rate, implantation rate, pregnancy rate and miscarriage rate, which were statistically analyzed using Mann-Whitney U test or Fisher's exact test, where appropriate. Results: In 9 out of the 92 cycles where ICSI was planned with fresh testicular spermatozoa, testicular spermatozoa could not be retrieved. Fertilization rate tended to be higher in the fresh group than in the cryopreserved-thawed group (58.0¡¾27.8% vs. 45.9¡¾25.0%, p=0.076). The number of high quality embryos was significantly higher in the fresh group (0.9¡¾1.2 vs. 0.2¡¾0.5, p=0.002). However, there were no significant differences in clinical pregnancy rate, implantation rate and miscarriage rate between the two groups. Conclusion: The results of this study suggest that although the use of cryopreserved-thawed testicular sperm for ICSI in patients with azoospermia may reduce fertilization capacity and embryo quality, it may not affect pregnancy rate, implantation rate and miscarriage rate. If testicular sperm can be obtained before ICSI procedure, the use of cryopreserved-thawed testicular sperm may also avoid unnecessary controlled ovarian hyperstimulation and cancellation of oocyte retrieval when spermatozoa cannot be retrieved as well as damage on testicular function by repeated TESE.
키워드 : Azoospermia, Testicular sperm retrieval, Cryopreservation, Intracytoplasmic sperm injection
교신저자 : ymchoi@snu.ac.kr
전문 파일 : 
