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대한생식의학회지 제35권 제3호 2010년
비만하지 않은 다낭성난소증후군 환자에서 메트포민 효용성의 예비 연구
성균관대학교 의과대학 강북삼성병원 산부인과학교실
김계현, 김형옥
The Effect of Metformin in Non-Obese Women with Polycystic Ovary Syndrome; Pilot Study
Kye Hyun Kim
Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital,
.
Objective: This pilot study was performed to investigate the effect of metformin on insulin resistance, hormone levels, and lipid profiles in non-obese patients with polycystic ovary syndrome. Methods: This study included 16 non-obese patients with polycystic ovary syndrome diagnosed at our hospital from June 2006 to September 2007. Blood samples were collected before and 6 months after metformin treatment for analysis of fasting serum glucose levels, fasting serum insulin levels, a glycemic response to 75 g oral glucose tolerance test (OGTT), and hormonal blood profile including FSH, LH, estradiol, testosterone, free testosterone, serum lipid profiles. Insulin resistance was estimated by calculating fasting glucose/insulin ratio (FGIR), 2 hr glucose/insulin ratio after 75 g glucose load. And we investigated insulin resistance and pancreatic beta cell function by calculating HOMA beta cell function and HOMA IR. Results: After the treatment of metformin, there was significant increase in 2 hr glucose/insulin ratio after 75 g glucose load (p=0.04) and decrease in HOMA IR (p=0.000). But serum lipid profiles did not change significantly. Also the metformin treatment induced a significant reduction in serum free testosterone and LH levels, and LH/FSH ratio (p=0.001, p=0.000, p=0.034). Conclusion: This pilot study showed that metformin might be effective in improving insulin sensitivity, ameliorating hyperandrogenemia in non-obese patients with polycystic ovary syndrome. Further investigations with larger number of patients and long-term observations are necessary to determine the role of metformin.
키워드 : Metformin, Polycystic ovary syndrome, Insulin resistance, Hyperandrogenemia, 메트포민, 다낭성난소증후군, 인슐린 저항성, 고안드로겐혈증
교신저자 : kyehyunmd@hanmail.net
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