논문 및 학회지

대한생식의학회지   제19권 제1호 2010년

GnRH의 맥동성 투여에 의한 남성 성선기능저하증의 치료

연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 비뇨기과학교실;연세대학교 의과대학 비뇨기과학교실;연세대학교 의과대학 내과학교실;연세대학교 의과대학 내과학교실;

박기현;지용석;이병석;이보연;조동제;송찬호;이무상;최형기;이현철;허갑범;,

Pulsatile GnRH Therapy in Male Patients with Hypogonadotropic Hyprogonadism

Park, Ki-Hyun;Jee, Yong-Seok;Lee, Byung-Seok;Lee, Bo-Yun;Cho, Dong-Jae;Song, Chan-Ho;Lee, Moo-Sang;Choi, Hyung-Ki;Lee, Hyun-Chul;Heo, Kab-Beom;

Department of Obstetrics and Gynecology, Yonsei University College of Medicine;Department of Obstetrics and Gynecology, Yonsei University College of Medicine;Department of Obstetrics and Gynecology, Yonsei University College of Medicine;Department of Obstetrics and Gynecology, Yonsei University College of Medicine;Department of Obstetrics and Gynecology, Yonsei University College of Medicine;Department of Obstetrics and Gynecology, Yonsei University College of Medicine;Department of Urology, Yonsei University College of Medicine;Department of Urology, Yonsei University College of Medicine;Department of Internal Medicine, Yonsei University College of Medicine;Department of Internal Medicine, Yonsei University College of Medicine;

The effects of pulsatile GnRH therapy have been studied for the treatment of different forms of hypogonadotropic hypogonadism, including idiopathic hypogonadotropic hypogonadism and hypogonadism developed as a result of treatment with combination of surgery and irradiation for pituitary or hypothalamic tumor. GnRH was administered subcutaneously in a dose of $10{\mu}g$ every 2 hours with the pulsatile infusion pump. With GnRH therapy, all patients improved secretion of LH, FSH and testosterone. Testicular volumes increased. Spermatogenesis was induced in 8 patients. Pulsatile GnRH therapy is an effective treatment for idiopathic hypogonadotropic hypogonadism and can have a role in hypogonadism previously treated with combination of surgery and irradiation for pituitary or hypothalamic tumor.

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