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대한생식의학회지 제21권 제1호 2010년

다낭성 난소 증후군 환자에서 비만군과 비비만군에서의 인슐린 저항성

연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 내과학교실;

임영구;이병석;조은정;차동현;박원일;박기현;조동제;이국;송찬호;이은직;,

Insulin Resistance in Obese and Non-obese Patients with Polycystic Ovarian Syndrome

Lim, Y.K.;Lee, B.S.;Cho, E.J.;Cha, D.H.;Park, W.I.;Park, K.H.;Cho, D.J.;Lee, K.;Song, C.H.;Lee, E.J.;

Department of Obstesterics and Gynecology, Yonsel University College of Medicine;Department of Obstesterics and Gynecology, Yonsel University College of Medicine;Department of Obstesterics and Gynecology, Yonsel University College of Medicine;Department of Obstesterics and Gynecology, Yonsel University College of Medicine;Department of Obstesterics and Gynecology, Yonsel University College of Medicine;Department of Obstesterics and Gynecology, Yonsel University College of Medicine;Department of Obstesterics and Gynecology, Yonsel University College of Medicine;Department of Obstesterics and Gynecology, Yonsel University College of Medicine;Department of Obstesterics and Gynecology, Yonsel University College of Medicine;Department of Internal Medicine Yonsel University College of Medicine;

This study was designed to investigate the relationship between insulin resistance and obesity in the pathogenesis of polycystic ovarian syndrome(PCO). Twenty-two women with PCO, of whom thirteen were non-obese with body mass index(BMI, kg/$m^2$) of <25 and nine were obese with BMI${\geq}$25 were studied. Eight non-obese control women and seven obese control women were studied. Serum concentrations of testosterone, lutenizing hormone(LH)/follicle-stimulating hormone(FSH) ratio, and insulin-like growth factor I (IGF-I) were found to be significantly higher(P<0.05) in PCO women compared with control women, which clearly is not related to obesity. Serum glucose, insulin, and C-peptide levels were measured during a 2-hour oral glucose tolerance test(OGTT). Non-obese and obese women with PCO both(P<0.05) compared with control women demonstrated significant hyperinsulinemia after OGTT. The degree of hyperinsulinemia was found to be significantly higher in the obese women with PCO compared with the non-obese women with PCO. We concluded that obesity may contribute to hyperinsulinemia, however may not playa central role in the pathogenesis of PCO.

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