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대한생식의학회지 제22권 제2호 2010년
고환조직 정자채취술 (TESE)의 정자 상태에 따른 세포질내 정자주입술의 (ICSI)수정률과 임신율
제일병원 불임연구실;제일병원 불임연구실;제일병원 불임연구실;제일병원 불임연구실;제일병원 비뇨기과;제일병원 비뇨기과;제일병원 산부인과;제일병원 산부인과;
전진현;김정욱;박용석;이호준;서주태;이유식;손일표;전종영;,
Fertilization and Pregnancy Rate of Testicular Sperm Extraction(TESE) with Intracytoplasmic Sperm Injection(ICSI)
Jun, Jin-Hyun;Kim, Jeong-Wook;Park, Yong-Seog;Lee, Ho-Joon;Seo, Ju-Tae;Lee, Yu-Sik;Son, Il-Pyo;Jun, Jong-Young;
Infertility Research Laboratory, Cheil General Hospital;Infertility Research Laboratory, Cheil General Hospital;Infertility Research Laboratory, Cheil General Hospital;Infertility Research Laboratory, Cheil General Hospital;Department of Obstretrics and Gynecology, Cheil General Hospital;Department of Obstretrics and Gynecology, Cheil General Hospital;Department of Urology, Cheil General Hospital;Department of Urology, Cheil General Hospital;
In IVF-ET program, intracytoplasmic sperm injection(ICSI) has been performed with testicular sperm extraction(TESE) in case of no normal spermatozoon could be retrieved from the epididymis. We wished to see whether the quality of testicular sperm affect the fertilization and pregnancy rate in TESE-ICSI cycles(n=40). These cycles were classified into three groups by the total number of normal motile spermatozoa(TNMS) in the TESE sample: i) good sperm(GS) group(n=12), TNMS > 10,000; ii) moderate sperm(MS) group(n=19), 1,000 < TNMS < 10,000; iii) poor sperm(PS) group(n=9), TNMS < 1,000. Among 423 injected oocytes, 307(72.6%) oocytes were normally fertilized and 43 zygotes were cryopreserved. The fertilization rates of GS group(79.3%) and MS group(75.9%) were significantly(p<0.005) higher than PS group(60.2%). After the embryo transfer(n=40), clinical pregnancy was obtained in 14 cycles(35.0%) and on-going pregnacy in 13 cycles(32.5%). The clinical and on-going pregnancy rates were similar in each group. From these results it can be concluded that testicular spermatozoa are successfully used with ICSI in IVF-ET program in spite of very poor quality of TESE sample.
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