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대한생식의학회지 제22권 제2호 2010년
인간의 체외수정배아이식술에서 보조부화술이 임신률에 미치는 영향에 관한 연구
제일병원 불임연구실;제일병원 불임연구실;제일병원 불임연구실;제일병원 불임연구실;제일병원 불임연구실;제일병원 불임연구실;
이호준;김정욱;변혜경;전진현;손일표;전종영;,
The Effect of Assisted Hatching (AHA) on Pregnancy Rates in Human IVF-ET
Lee, H.J.;Kim, J.W.;Byun, H.K.;Jun, J.H.;Son, I.P.;Jun, J.Y.;
Infertility Research Laboratory, Cheil General Hospital;Infertility Research Laboratory, Cheil General Hospital;Infertility Research Laboratory, Cheil General Hospital;Infertility Research Laboratory, Cheil General Hospital;Infertility Research Laboratory, Cheil General Hospital;Infertility Research Laboratory, Cheil General Hospital;
In human IVF-ET, the development and morphology of the embryo have been known to affect implantation and pregnancy rates(PRs). Recently, pregnancy has been reported to related to the embryos with thick zona-pellucida, high levels of fragmentation, poor blastomere development and zona hardening. Although the mechanism of implantation is unclear, it is thought that the hatching process precedes implantation and that the hatching is related to implantation and PRs. This study was carried out to investigate the effect of assisted hatching(AHA) on the improvement of PRs in human IVF-ET. The results were as follows; 1. The PRs of the AHA group (40.8%) was significantly higher than that of control group(27.2%)(P<0.01). 2. According to the age of patients, the PRs of control and AHA groups were 33.9%(20/59), 44,4%(12/27) in <30 yrs, 26.1%(30/115), 38.3%(18/47) in 31-35 yrs, 22.4%(13/58), 41.4%(12/29) in >36 yrs, respectively. 3. According to the factors of infertility in AHA group, unexplained(immunologic factor) (40.0%) and male factors(41.9%) were higher than female(tubal obstruction, endometriosis, adhesion) factor (28.9%). As a result, it is suggested that AHA technique improve the PRs in poor prognosis patients. It is concluded that AHA method can be used to improve the PRs in human lVF-ET.
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