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대한생식의학회지 제22권 제2호 2010년

수정에 실패한 인간 난자에 있어서의 염색체의 수의 이상

차병원 여성의학연구소;차병원 여성의학연구소;차병원 여성의학연구소;차병원 여성의학연구소;차병원 여성의학연구소;차병원 여성의학연구소;차병원 여성의학연구소;차병원 여성의학연구소;

손원영;이경아;박상희;한세열;윤태기;정형민;곽인평;차광열;,

Chromosomal Abnormalities in Human Oocytes Fail to Fertilize after Insemination In Vitro

Son, Weon-Young;Lee, Kyung-Ah;Park, Sang-Hee;Han, Sei-Yul;Yoon, Tae-Ki;Jung, Hyung-Min;Kwak, In-Pyung;Cha, Kwang-Yul;

Infertility Medical Center, Genetics Laboratory, Cha General Hospital;Infertility Medical Center, Genetics Laboratory, Cha General Hospital;Infertility Medical Center, Genetics Laboratory, Cha General Hospital;Infertility Medical Center, Genetics Laboratory, Cha General Hospital;Infertility Medical Center, Genetics Laboratory, Cha General Hospital;Infertility Medical Center, Genetics Laboratory, Cha General Hospital;Infertility Medical Center, Genetics Laboratory, Cha General Hospital;Infertility Medical Center, Genetics Laboratory, Cha General Hospital;

Many oocytes fail to fertilize and cleave in vitro and many embryos transferred back to uterus fail to implant or maintain implantation. Chromosomal abnormalities in the male and female gametes may contribute to this loss. The higher incidence of meiotic chromosomal abnormalities bas been found in oocytes than in sperm. The wide range of incidence of chromosomal abnormalities in unfertilized oocytes has been reported in human IVF program (26-63%). However, factors affecting chromosomal abnormalities are not well understood. The present study has been conducted to investigate effects of the method for ovarian hyperstimulation, women's age, and the number of oocytes retrieved per patients on the incidence of numerical chromosomal abnormalities. Five hundred eighty four unfertilized metaphase II oocytes were subjected to chromosomal analysis. Included unfertilized oocytes were from 220 patients (mean $age=32.7{\pm}3.0$) and three hundred thirty oocytes were legible for analysis. Two hundred fourty five oocytes out of 330 (73.3%) were normal, while 38 (11.5%) were hyperploidy, 35 (10.6%) were hypoploidy, and 12 (3.6%) were diploidy. Significant difference in chromosomal abnormalities was not found between two patient groups stimulated by follicular stimulating hormone/human menopausal gonadotrophin (FSH/HMG) (25.9%) and gonadotrophin-releasing hormone agonist/follicular stimulating hormone/human menopausal gonadotrophin (GnRHa/FSH/HMG) (28%). There was a tendency of increasing chromosomal abnormalities in unfertilized oocytes from older patients (<30 yrs: 20.3%, 30-34yrs: 26.9%, >34 yrs: 35.3%). The number of oocytes retrieved per patient had no effect the incidence of chromosomal abnormalities (1-5: 31. 4%, 6-10: 29.8%, 11-15: 28.6%, > 15: 16.5%). These results from the present study suggest that the chromosomal abnormalities observed in the unfertilized oocytes has not affected by the stimulation methods, patient's age, and the number of oocytes retrieved per patients.

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