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대한생식의학회지 제24권 제1호 2010년
정장액내의 금속성분이 정액지표 및 가임능에 미치는 영향
부산대학교 의과대학 비뇨기과학교실;부산대학교 의과대학 비뇨기과학교실;부산대학교 의과대학 비뇨기과학교실;
박남철;김민수;윤종병;,
Effect of Metal Components in Seminal Plasma on Seminal Parameter and Male Fertile Ability
Park, Nam-Cheol;Kim, Min-Soo;Yoon, Jong-Byung;
Department of Urology, College of Medicine, Pusan National University;Department of Urology, College of Medicine, Pusan National University;Department of Urology, College of Medicine, Pusan National University;
To determine the concentration and the physiologic role of metal components in blood plasma and seminal plasma in relation to male infertility, the concentrations of twelve metal components in blood plasma and seminal plasma including Na, Mg, K, Ca, Cr, Mn, Fe, Cu, Zn, Se, Cd and Pb were measured by atomic absorbance spectrophotometery or ion selective electrode analysis. Semen and blood samples were obtained from a total of 110 men including 70 male infertility patients, 20 vasectomized persons and 20 fertility proven volunteers visited to the Male Infertility Clinic of Pusan National University Hospital. The concentrations of Ca, Zn, Mg, Cr and Cd in control group were higher in seminal plasma than in blood plasma, and additionally Pb were higher in infertility group. The concentrations of all metal components revealed no significant difference according to patients' age, resident, occupation, sperm density, motility and hormone level in blood plasma, but some metal components including Ca, Mg, Cu, Mn, Cd and Pb revealed a significant difference according to each these parameters except patient's age in seminal plasma. The concentrations of Mn, Cd and Pb in the vasectomy persons were higher than in the infertility group III including testicular and epididymal factors, but not in blood plasma. We conclude that the quantitative changes of metal components in the seminal plasma may have effects on not only spermatogenesis and sperm function, but also contribute to diagnostic parameter according to organ specificity of the metal in the male reproduction.
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