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대한생식의학회지 제24권 제1호 2010년
고환조직 정자채취술과 세포질내 정자주입술을 이용한 고환조직 정자의 수정률과 임신율
삼성제일병원 불임연구실;삼성제일병원 비뇨기과;삼성제일병원 불임연구실;삼성제일병원 불임연구실;삼성제일병원 비뇨기과;삼성제일병원 비뇨기과;삼성제일병원 산부인과;삼성제일병원 산부인과;삼성제일병원 불임연구실;
박용석;서주태;전진현;변혜경;김종현;이유식;손일표;강인수;이호준;,
Fertilization and Pregnancy Rate of Testicular Sperm after Testicular Sperm Extraction (TESE) with Intracytoplasmic Sperm Injection(ICSI)
Park, Yong-Seog;Seo, Ju-Tae;Jun, Jin-Hyun;Byun, Hye-Kyung;Kim, Jong-Hyun;Lee, You-Sik;Son, Il-Pyo;Kang, Inn-Soo;Lee, Ho-Joon;
Infertility Research Laboratory, Samsung Cheil Hospital & Women's Healthcare Center;Department of Urology, Samsung Cheil Hospital & Women's Healthcare Center;Infertility Research Laboratory, Samsung Cheil Hospital & Women's Healthcare Center;Infertility Research Laboratory, Samsung Cheil Hospital & Women's Healthcare Center;Department of Urology, Samsung Cheil Hospital & Women's Healthcare Center;Department of Urology, Samsung Cheil Hospital & Women's Healthcare Center;Department of Obstetrics and Gynecology, Samsung Cheil Hospital & Women's Healthcare Center;Department of Obstetrics and Gynecology, Samsung Cheil Hospital & Women's Healthcare Center;Infertility Research Laboratory, Samsung Cheil Hospital & Women's Healthcare Center;
This study was carried to determine the possibility of finding motile spermatozoa and fertilization, pregnancy rate after testicular sperm extraction(TESE) with ICSI in obstructive and non-obstructive azoospermic patients. In 154 cases(132 patients), obstructive azoospermia was 77 cases and non-obstructive azoospermia was 77 cases. In obstructive azoospermia, patients generally showed normal spermatogenesis and included vas agenesis(n=8), multiple vas obstruction(n=7), epididymal obstruction (n=54). Total of 982 retrieved oocytes were obtained and 84.4% were injected. The fertilization rates with 2 PN and cleavage rate were 72.5% and 62.3%, respectively. 30 pregnancies(38.9%) were achieved and the ongoing pregnancies were 22 cases (28.6%). In non-obstructive azoospermia, patients showed hypospermatogenesis(n=49), maturation arrest(n=4), Sertoli cell only syndrome (n=24). The various stages of spermatogenic cell could be retrieved by TESE and could be reached normal fertilization and embryo development with ICSI. Total of 1072 retrieved oocytes obtained and 80.2% were injected. The fertilization rates with 2 PN and cleavage rate were 52.8% and 68.9%, respectively. 22 pregnancies(30.1%) were achieved and the ongoing pregnancies were 19 cases(26.0%). Conclusively, the combination of TESE with ICSI using testicular spermatozoa can achieve normal fertilization and pregnancy rate and effective method in obstructive and non-obstructive azoospermic patients.
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