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대한생식의학회지 제24권 제1호 2010년
일반적인 체외수정 방법과 세포질내 정자주입술로 얻어진 배아의 동결-융해 후 이식의 결과
삼성제일병원 불임연구실;삼성제일병원 불임연구실;삼성제일병원 불임연구실;삼성제일병원 불임연구실;산부인과 불임클리닉;산부인과 불임클리닉;산부인과 불임클리닉;산부인과 불임클리닉;삼성제일병원 불임연구실;
김정욱;한미현;변혜경;전진현;손일표;궁미경;백은찬;강인수;이호준;,
Results of Transfer of Cryopreserved Supernumerary Embryos Obtained after Conventional in vitro Fertilization and Intracytoplasmic Sperm Injection (ICSI)
Kim, Jeong-Wook;Han, Mi-Hyun;Byun, Hye-Kyung;Jun, Jin-Hyun;Son, Il-Pyo;Koong, Mi-Kyoung;Paik, Eun-Chan;Kang, Inn-Soo;Lee, Ho-Joon;
Infertility Research Laboratory, Samsung Cheil Hospital & Women's Healthcare Center;Infertility Research Laboratory, Samsung Cheil Hospital & Women's Healthcare Center;Infertility Research Laboratory, Samsung Cheil Hospital & Women's Healthcare Center;Infertility Research Laboratory, Samsung Cheil Hospital & Women's Healthcare Center;Department of Obstetrics and Gynecology, Samsung Cheil Hospital & Women's Healthcare Center;Department of Obstetrics and Gynecology, Samsung Cheil Hospital & Women's Healthcare Center;Department of Obstetrics and Gynecology, Samsung Cheil Hospital & Women's Healthcare Center;Department of Obstetrics and Gynecology, Samsung Cheil Hospital & Women's Healthcare Center;Infertility Research Laboratory, Samsung Cheil Hospital & Women's Healthcare Center;
Intracytoplasmic sperm injection (ICSI) recently has been utilized widely as the most successful technique to overcome the unfertilization problem in cases of severe male infertility in couples who could not be treated by conventional IVF. Recently, indications of ICSI have been extended further and more fertilized oocytes become available. Thus, it is necessary to examine the efficiency of freezing the surplus embryos obtained from ICSI. We compared the survival rate and the future outcome of cryopreserved embryos obtained either after conventional IVF or ICSI during the same period. After ICSI or IVF, five best-quality embryos from each patient were transferred in the stimulation cycle and the surplus pronuclear (PN) stage oocytes or multicellular embryos were cryopreserved by slow freezing protocol with 1,2-propanediol (PROH) as a cryoprotectant. A total of 792 embryos from ICSI trial were thawed and 65.2% (516/792) survived. The survival rates of PN stage oocyte, multicellular embryo and PN + multicellular embryo were 63.5%, 68.2%, 64.0%, respectively. After 111 transfers, 34 pregnancies were achieved, corresponding to a clinical pregnancy rate of 30.6% per transfers. We thawed 1033 embryos from IVF trials and 57.5% (594/1033) survived. In IVF cycle, the survival rates of PN stage oocyte, multicellular embryo and PN + multicellular embryo were 58.2%, 65.2%, 40.2%, respectively. Thirty eight clinical pregnancies were established after 134 transfers, corresponding to a pregnancy rate of 28.4% per transfer. The cleavage rate of thawed PN stage oocytes from ICSI trial (61.3%) was significantly higher than those from conventional IVF (53.4%). The developmental rates of good embryo (
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