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대한생식의학회지 제25권 제2호 2010년
Ketamine과 Pentobarbitone이 생쥐 난자의 퇴화 및 과립세포의 자연세포사에 미치는 영향
한양대학교 자연과학대학 생물학과
김종훈, 윤용달,
Effects of Ketamine and Pentobarbitone on Degeneration of Oocyte and Apoptosis of Granulosa Cells in Mouse Ovary
Kim jh, Yoon yd
Department of Biology, College of Natural Sciences, Hanyang University
In mammal, lots of follicles start simultaneously their growth but only a few oocytes are ovulated in every sexual cycles. Most of matured and grown oocytes are destined to degenerate by atresia. However, the molecular and physiological mechanisms are not elucidated yet. The present study was designed to establish an induction method of follicular atresia with ketamine or pentobarbitone and evaluate the effect of these anesthetics on oocyte maturation and granulosa cell apoptosis of the mouse ovarian follicle. The percentages of degenerated oocyte and apoptotic granulosa cell in ketamine treated groups were significantly higher than that in controls(58.9% vs 33.5%, p < 0.01, degeneration; 44.9% vs 26.6%, p < 0.01, apotosis). Futhermore, it was revealed that the concentrations of progesterone in both groups were markedly higher than that in control. In conclusion, it is considered that ketamine induce an atresia as pentobarbitone, and may be useful for inducing follicular atresia.
키워드 : Ketamine, Pentobarbitone, Atresia, Apoptosis, Oocyte, Ovary, Mouse
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