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대한생식의학회지 제35권 제1호 2010년
Dexamethasone이 황체용해에 미치는 영향에 관한 면역조직화학적 연구
충남대학교 의과대학 산부인과학교실1, 해부학교실2
박선희1, 고영복1, 이윤이1, 노흥태1*, 김원식2,
Immunohistochemical Study on the Effect of Dexamethasone on the Luteolysis of Corpus Luteum of the Rat
Sun-Hee Park1, Young-Bok Ko1, Yun-Ee Rhee1, Heung-Tae Noh1*, Won-Sik Kim2
1Department of Obstetrics and Gynecology, 2Depatment of Anatomy, College of Medicine, Chungnam National University, Daejon, Korea
Objective: This study was attempted to look at the effect of dexamethasone on the luteolysis of corpus luteum in rats by immunohistochemical study. Methods: Counting with an optical microscope was conducted to make a comparison on difference in luteolysis and penetration of macrophage into three groups: control group of 30 female rats at 8 weeks of age, dexamethasone 0.1 mg administered group, and dexamethasone 1mg administered group. Results: As a result of TUNEL immunostaining, the percentage of luteolysis was significantly reduced in both dexamethasone 0.1 mg administered group and 1 mg administered group, and after ED1 immunostaining, macrophage invasion was reduced in dexamethasone 1 mg administered group. As a consequence of ED1 immunostaining, the immune response of macrophage was much decreased in dexamethasone 1 mg administered group than control group. Conclusion: Dexamethasone works on luteal cell, so it can suppress apoptosis. It can suppress luteolysis by suppression macrophage invasion into corpus luteum or suppress macrophage activation in corpus luteum.
키워드 : Dexamethasone, Corpus luteum, Luteolysis
교신저자 : nht@cnuh.co.kr
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