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대한생식의학회지 제19권 제1호 2010년
폐경전 무월경 여성에 있어서 골밀도 측정에 관한 연구
연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;
박기현;이병석;이보연;조동제;송찬호;,
Bone Mineral Density in Premenopausal Amenorrheic Women with Hypogonadism
Park, Ki-Hyun;Lee, Byung-Seok;Lee, Bo-Yon;Cho, Dong-Jae;Song, Chan-Ho;
Department of Obstetrics and Gynecology, Yonsei University, College of Medicine;Department of Obstetrics and Gynecology, Yonsei University, College of Medicine;Department of Obstetrics and Gynecology, Yonsei University, College of Medicine;Department of Obstetrics and Gynecology, Yonsei University, College of Medicine;Department of Obstetrics and Gynecology, Yonsei University, College of Medicine;
Bone mineral density was measured to assess whether the patients with premonopausal hypogonadism, comprised of 19 patients with hypogonadotropic hypogonadism(HH), 55 with premature ovarian failure(POF), 23 with hyperprolactinemia(HPLN), and 8 with Sheehan's syndrome. All aged from 20 to 39, were associated with some decrease in regional bone mass compared with that of 63 normal-associated with some decrease in regional bone mass compared with that of 63 normal-cycling control women matched with age and sex. Measurement of bone mineral density was carried out using Dual photon absorptiometry at four sites; femur neck, ward's triangle, trochanter and spine(L2-L4). Bone mineral density at all four sites were significantly decreased in patients with HH(p<0.01), POF(p<0.01). In hyperprolactinemic patients, the decrease in bone mass was significant at femur neck and Ward's triangle(p<0.05). The patients with POF were noted to be associated with significant bone loss when their duration of amenorrhea exceeded one year. In this study, the degree of loss of bone mass and the affected sites seemed to be different depending on the various types of hypogonadism and POF was noted have caused the appearance of loss of bone mass earlier than other thpes of hypogondism we experienced.
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