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대한생식의학회지 제15권 제2호 2010년

흰쥐 자궁 및 착상에 있어서 Tamoxifen과 성스테로이드 호르몬의 상호관계

서울대학교 수의과대학 생리학교실;서울대학교 수의과대학 생리학교실;서울대학교 수의과대학 생리학교실;서울대학교 수의과대학 생리학교실;

한호재;유규연;권종국;양일석;,

Relationship between Tamoxifen and Sex Steroid Hormones on Uterus and Implantation in Rat

Han, H.J;Yoo, K.Y.;Kwun, J.K.;Yang, I.S.;

Department of Veterinary Physiology. College of Veterinary Medicine Seoul National University;Department of Veterinary Physiology. College of Veterinary Medicine Seoul National University;Department of Veterinary Physiology. College of Veterinary Medicine Seoul National University;Department of Veterinary Physiology. College of Veterinary Medicine Seoul National University;

These studies were undertaken to examine the relationship between tamoxifen and sex steroid hormones in rat uterine morphology and the effect of tamoxifen on sex steroid hormone levels, implantation and myometrial contraction. The results obtained were as follows : 1) The increase in height of the luminal epithelium caused by tamoxifen treatment was blocked by progesterone. The increase in height of luminal epithelium caused by $estradiol-17{\beta}$ treatment was blocked by tamoxifen. 2) When a single dose of tamoxifen(10, 20, $40{\mu}g$) was given on Day 2 of pregnancy, implantation was prevented. Plasma $estradiol-17{\beta}$ level fell in a dose-dependent manner but plasma progesterone level was constant. 3) In vitro, tamoxifen decreased rat uterine contractility in a dose-dependent manner.

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